Cognitive & Neuroprotective Peptide
Semax
ACTH(4-10) analog heptapeptide studied for neuroprotection and BDNF expression.
Overview
Semax is a synthetic heptapeptide based on the 4–10 fragment of adrenocorticotropic hormone (ACTH), modified with a C-terminal Pro-Gly-Pro to resist enzymatic breakdown. The modification removes the hormonal activity of ACTH while retaining neurotropic effects, making it a research tool for cognition and neuroprotection.
Published studies associate Semax with increased expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor, and examine its effects in models of ischemia, cognitive performance, and neuronal survival.
Specification
| 0 | Sequence, Met-Glu-His-Phe-Pro-Gly-Pro |
|---|---|
| 1 | Molecular formula, Cu2083u2087Hu2085u2081Nu2089Ou2081u2080S |
| 2 | Molecular weight, 813.9 g/mol |
| 3 | CAS number, 80714-61-0 |
| 4 | Synonyms, ACTH(4-7)-Pro-Gly-Pro, MEHFPGP |
Research areas
- Neuroprotection
- BDNF / NGF expression
- Cognitive research
- Ischemia models
References
- 1. Semax, an analog of ACTH(4-10), increases brain-derived neurotrophic factor protein in rat basal forebrain Journal of Histochemistry & Cytochemistry 2006 Dolotov OV, et al.
- 2. Effects of Semax and its Pro-Gly-Pro fragment on the expression of neurotrophin genes in the rat hippocampus Molecular Biology 2007 Medvedeva EV, et al.
