Cognitive & Anxiolytic Peptide
Selank
Synthetic tuftsin-analog heptapeptide studied for anxiolytic and cognitive endpoints.
Overview
Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, stabilized with additional residues to extend its activity. It was developed as a research analog for studying anxiety and cognition without the sedation associated with classic anxiolytics.
Investigations describe effects on the balance of monoamine neurotransmitters, modulation of BDNF expression, and neuroimmune signaling. Selank is studied in behavioral and molecular models of stress, anxiety, and memory.
Specification
| 0 | Sequence, Thr-Lys-Pro-Arg-Pro-Gly-Pro |
|---|---|
| 1 | Molecular formula, Cu2083u2083Hu2085u2087Nu2081u2081Ou2089 |
| 2 | Molecular weight, 751.9 g/mol |
| 3 | CAS number, 129954-34-3 |
| 4 | Synonyms, TP-7, Tuftsin analog |
Research areas
- Anxiolytic research
- BDNF expression
- Cognitive function
- Neuroimmune modulation
References
- 1. Efficacy and possible mechanisms of action of a new peptide anxiolytic Selank in generalized anxiety disorder and neurasthenia Zhurnal Nevrologii i Psikhiatrii 2008 Zozulia AA, et al.
- 2. Regulatory peptide Selank and its effect on the expression of inflammation-related genes Molecular Biology 2014 Kolomin T, et al.
