Cellular Coenzyme
NAD+
Essential redox coenzyme central to energy metabolism and cellular-aging research.
Overview
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell, where it shuttles electrons between reactions as part of central energy metabolism. Cellular NAD+ availability declines with age, which has made it a focal point of metabolic and longevity research.
Beyond its redox role, NAD+ is consumed as a substrate by sirtuins and PARP enzymes involved in gene regulation and DNA repair. Studies of NAD+ and its precursors examine mitochondrial function, sirtuin signaling, and age-related metabolic decline in cell and animal models.
Specification
| 0 | Molecular formula, Cu2082u2081Hu2082u2087Nu2087Ou2081u2084Pu2082 |
|---|---|
| 1 | Molecular weight, 663.43 g/mol |
| 2 | CAS number, 53-84-9 |
| 3 | Synonyms, u03b2-NAD, Nicotinamide adenine dinucleotide |
Research areas
- Mitochondrial energy metabolism
- Sirtuin activation
- DNA-repair research
- Redox balance
- Cellular-aging research
References
- 1. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence Cell Metabolism 2018 Rajman L, Chwalek K, Sinclair DA
- 2. NAD+ in aging, metabolism, and neurodegeneration Science 2015 Verdin E
- 3. Modulating NAD+ metabolism, from bench to bedside The EMBO Journal 2017 Katsyuba E, Auwerx J
