BUY 2, GET ANY VIAL FREE — added automatically at checkout
Copper Tripeptide

GHK-Cu

Copper-binding tripeptide studied for collagen synthesis and skin remodeling.

Overview

GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a sequence that occurs naturally in human plasma and declines with age. Its high affinity for copper lets it act as a carrier that delivers the trace metal into cells, where copper participates in the enzymatic steps of connective-tissue formation.

In published in-vitro and animal research the peptide has been associated with increased collagen and glycosaminoglycan production, modulation of metalloproteinase activity, and broad shifts in gene expression linked to tissue remodeling and antioxidant defense. It is widely used as a reference compound in skin-regeneration and wound-healing studies.

Specification

0 Sequence, Gly-His-Lys u00b7 Cuu00b2u207a
1 Molecular formula, Cu2081u2084Hu2082u2084Nu2086Ou2084u00b7Cu
2 Molecular weight, 403.9 g/mol
3 CAS number, 89030-95-5
4 Synonyms, Copper tripeptide-1, GHK-Copper

Research areas

  • Collagen synthesis
  • Skin remodeling
  • Wound-healing research
  • Antioxidant defense
  • Hair-follicle research

References

  1. 1. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data International Journal of Molecular Sciences 2018 Pickart L, Margolina A
  2. 2. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration BioMed Research International 2015 Pickart L, Vasquez-Soltero JM, Margolina A
  3. 3. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging BioMed Research International 2012 Pickart L, Vasquez-Soltero JM, Margolina A